Endocrine Abstracts

The USMBDPCP is unique that it is the first study to consider the whole US- Mexico Border as one epidemiological unit. The project goal is to reduce the burden of diabetes among persons with type 2 diabetes living in the U.S.-Mexico border region. I Development of a Prevalence Study and identification of risk factors. II Implementation an intervention pilot study for diabetes prevention and control.Phase IThe diabetes prevalence su...

IntroductionDiabetes, a metabolic disorder characterized by abnormal blood glucose levels, is a serious chronic disease that implies an important public health problem. Being Insulin the main hormone for modulating blood glucose levels, subcutaneous injections are the main way for its administration in the diabetes treatment. However, this way of administration can lead to poor patient compliance, apart from several side-effects. Although other ways of a...

Introduction: Prolactinoma is the most frequent secreting pituitary tumor. They are usually treated with dopamine agonists (DA) (bromocriptine and cabergoline), which are very effective in most cases. DA resistance consists of the impossibility of reaching normal prolactin levels and/or reduction of the adenoma by at least 50%.Case presentation: We present the case of a 57-year-old man affected by visual disturbances and hypopituitarism (2019). Pituitary...

Introduction: Esthesioneuroblastoma (ENB), also known as olfactory neuroblastoma, is a malignant neuroendocrine tumor of the nasal fossa that arises from neurosensory receptor cells of the olfactory epithelium. It represents 3% of all nasal tumors. It presents a slow and progressive evolution that primarily affects the upper nasal mucosa and cribriform plate, with subsequent extension to the entire cavity and paranasal sinuses and can invade the orbit and cranial base.<p c...

Objective: To describe the clinical characteristics of stroke in patients with prediabetes mellitus (pre-DM) and to compare them with DM and non-DM patient characteristics.Methods: Retrospective analysis of a prospective series of acute stroke patients. Demographic and clinical characteristics were compared among the three groups, along with outcome data. Stroke severity was evaluated by modified Rankin scale (mRS) and NIHSS (NIH stroke scale).<p cla...

Objective: To describe the clinical, aetiological and prognostic differences in diabetic and non-diabetic ischaemic stroke (IS) patients.Materials and methods: Retrospective analysis of prospective series of IS patients. Patients were classified as non-DM and DM patients. Demographic and clinical characteristics were compared between two groups. IS prognosis was evaluated by modified Rankin scale (mRS) and NIHSS (NIH stroke scale)....

Anaplastic thyroid carcinomas (ATC) are characterised by a poor prognosis, due to a highly proliferative, metastatic and undifferentiated state. Follicular thyroid cells undergo epithelial to mesenchymal transition (EMT) by the upregulation of TGFβ pathway. Interestingly, in many epithelial cancer types a correlation between high levels of SIX1 expression and TGFβ signaling has been described.Objective: Study the role of SIX1 homeoprotein in th...

The main product of the thyroid gland, T4, is a prohormone. 5’-deiodination is needed to convert T4 into the active, nuclear receptor-binding hormone, T3. Pharmacological modulation of activating 5’-and inactivating 5-deiodination of iodothyronines would be desirable in a number of medical conditions, including hypothyroidism, hyperthyroidism and various cancers. A structural and mechanistic understanding of deiodinase (DIO) catalysis...

Background: Both undernutrition and chronic inflammation impair linear growth through resistance to GH. Fibroblast growth factor 21 (FGF21) is known as an important regulator of the metabolic adaptation to fasting. Elevated expression of FGF21, secondary to prolonged undernutrition has been identified to develop GH resistance and subsequent attenuation of skeletal growth and growth plate chondrogenesis in both mice and human. However, the mechanism of FGF21’s actions rema...

Introduction: Ectopic thyroid glands are generally a rare entity appearing mostly in the cervical midline (90% of the cases) and even more rarely in other anatomical sites (10%).Clinical report: We present the case of an ectopic submandibular thyroid gland. A 31-year-old woman was referred to our department with a history of left submandibular swelling.A scintigraphy was performed, which showed an accumulation of activity in the ri...